SOD1 (EDI) Antibody: APC
Product Sizes
100 ug
SPC-206D-APC-100UG
About this Product
- SKU:
- SPC-206D-APC
- Additional Names:
- SEDI Antibody, SOD1 EDI Antibody, Superoxide dismutase 1 Antibody, SOD Antibody, SOD1 exposed dimer interface Antibody
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Conjugate:
- APC
- Concentration:
- 1 mg/ml
- Extra Details:
- Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (2). It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms (3). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (2). Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS). Therefore conformation specific antibodies such as SOD1 (EDI), which targets an exposed region of the dimer interface (EDI) of SOD1, are useful for determining the conformation of SOD1 in affected tissues (5). This antibody can be used in conjunction with SOD1 (UB BetaB) (SPC-205D) which detects an unfolded beta barrel (UB BetaB) of SOD1.
- Host:
- Rabbit
- Immunogen:
- C-terminal region of human SOD1, exposed dimer interface (EDI)
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Porcine, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes a conformation specific epitope where the dimer interface is exposed.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Polyclonal Antibody
