SOD1 (EDI) Antibody: ATTO 594
Product Sizes
100 ug
£481.00
SPC-206D-A594-100UG
About this Product
- SKU:
- SPC-206D-A594
- Additional Names:
- SOD1, Superoxide dismutase [Cu-Zn], Cu/Zn superoxide dismutase, SODC_HUMAN, ALS1, SOD1 EDI, SEDI, SOD1 exposed dimer interface, Conformationally altered SOD1, Misfolded SOD1, Apo-SOD1, Superoxide dismutase 1, SOD
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Clonality:
- Polyclonal
- Conjugate:
- ATTO 594
- Concentration:
- 1 mg/ml
- Extra Details:
- Superoxide dismutase 1 (SOD1) is a cytosolic antioxidant enzyme that catalyzes the dismutation of superoxide radicals (O₂-) into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂), playing a vital role in cellular redox homeostasis. Structurally, SOD1 is a 32 kDa homodimer, with each 16 kDa subunit stabilized by copper and zinc ions, an intra-subunit disulfide bridge, and a tightly packed B Beta-barrel fold. In neurodegenerative disease research-particularly amyotrophic lateral sclerosis (ALS)-SOD1 misfolding and aggregation are key pathological features. One critical conformational change involves the exposure of the dimer interface (EDI), a normally buried region essential for SOD1 stability and enzymatic function. This structural disruption is associated with toxic gain-of-function mechanisms and neuronal degeneration. Conformation-specific antibodies such as SOD1 (EDI) are designed to selectively recognize this exposed dimer interface, enabling researchers to detect early misfolding events in ALS-affected tissues. When used in combination with antibodies like SOD1 (UB BetaB) (catalog# SPC-205), which targets the unfolded B Beta-barrel region, these tools provide a powerful means of mapping SOD1 conformational states and tracking disease progression. Targeting the exposed dimer interface of SOD1 offers a promising strategy for understanding ALS pathogenesis and developing precision diagnostics and therapeutics in neurodegenerative disease research.
- Host:
- Rabbit
- Immunogen:
- C-terminal region of human SOD1, exposed dimer interface (EDI)
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Porcine, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes a conformation specific epitope where the dimer interface is exposed.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Polyclonal Antibody
