SOD1 (UbetaB) Antibody: HRP
Product Sizes
100 ug
£465.00
SPC-205D-HRP-100UG
About this Product
- SKU:
- SPC-205D-HRP
- Additional Names:
- SOD1 (UbetaB), SOD1, Superoxide dismutase [Cu-Zn], Cu/Zn superoxide dismutase, SODC_HUMAN, ALS1, USOD, SOD1 unfolded beta barrel region, Misfolded SOD1, Conformationally altered SOD1, Apo-SOD1, Superoxide dismutase 1, SOD
- Application:
- ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide, 0.23mM Citrate
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Clonality:
- Polyclonal
- Conjugate:
- HRP
- Concentration:
- 1 mg/ml
- Extra Details:
- Superoxide dismutase 1 (SOD1) is a copper- and zinc-binding antioxidant enzyme that catalyzes the dismutation of superoxide radicals (O₂-) into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂), thereby mitigating oxidative stress in the cytoplasm. Structurally, SOD1 functions as a 32 kDa homodimer, with each 16 kDa subunit stabilized by an intra-subunit disulfide bond and a B Beta-barrel fold critical for its enzymatic activity and structural integrity. In neurodegenerative disease research-particularly amyotrophic lateral sclerosis (ALS)-SOD1 has emerged as a central player. Mutations in the SOD1 gene can lead to protein misfolding, aggregation, and toxic gain-of-function effects. A key pathological hallmark involves the exposure of normally buried regions of the B Beta-barrel, including the unfolded B Beta-barrel domain, which is implicated in early misfolding events. Conformation-specific antibodies such as Anti-SOD1 (UbetaB), which selectively binds the unfolded B Beta-barrel region, are powerful tools for detecting misfolded SOD1 in affected tissues. When used alongside antibodies like Anti-SOD1 (EDI) (catalog# SPC-206), which targets the exposed dimer interface, researchers can map conformational states of SOD1 and track disease progression at the molecular level. Understanding and detecting these structural transitions in SOD1 is essential for advancing ALS diagnostics and developing targeted therapeutics in neurodegenerative disease research.
- Host:
- Rabbit
- Immunogen:
- Within 50 AA of N-terminal region of human SOD1, unfolded beta barrel region
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes a conformation specific epitope where the beta barrel is unfolded.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Polyclonal Antibody
