Alpha B Crystallin Antibody: ATTO 594
Product Sizes
200 ul
SPC-126B-A594-200UL
About this Product
- SKU:
- SPC-126B-A594
- Additional Names:
- AACRYA Antibody, Alpha crystallin B chain Antibody, CRYA2 Antibody, CRYAB Antibody, CTPP2 Antibody, HSPB5 Antibody, NY REN 27 antigen Antibody
- Application:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Conjugate:
- ATTO 594
- Concentration:
- 1 mg/ml
- Extra Details:
- The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to human alpha B crystallin conjugated to KLH
- Purification:
- Affinity Purified
- Reactivities:
- Avian, Bovine, Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~22kDa. Does not cross-react with A AlphaA-crystallin.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Polyclonal Antibody
