Alpha Synuclein Oligomer Antibody, Clone 9D2: FITC
Product Sizes
100 ug
£515.00
SMC-622D-FITC-100UG
About this Product
- SKU:
- SMC-622D-FITC
- Additional Names:
- Alpha-synuclein oligomer, A Alpha-synuclein oligomer, A Alpha-syn oligomer, Oligomeric alpha-synuclein, Oligomeric A Alpha-syn, Synuclein oligomer, SNCA oligomer, Soluble alpha-synuclein oligomer, Prefibrillar alpha-synuclein oligomer, Protofibrillar alpha-synuclein, Alpha-syn protofibril, A Alpha-syn protofibril, Alpha-synuclein aggregated species, Oligomeric synuclein species, Pathological alpha-synuclein oligomer
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 9D2
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Concentration:
- 1 mg/ml
- Extra Details:
- Alpha synuclein oligomers represent a soluble, neurotoxic form of the presynaptic protein and are increasingly recognized as early drivers of pathology in neurodegenerative disease. These oligomeric species disrupt synaptic vesicle trafficking and neurotransmission, impairing presynaptic function well before the formation of mature fibrillar aggregates. Localized effects extend to mitochondria, where oligomers induce oxidative stress, lysosomal dysfunction, and endoplasmic reticulum stress, contributing to neuronal vulnerability in Parkinson's disease (PD) and related synucleinopathies. Their capacity to propagate in a prion-like manner and initiate early synaptic and inflammatory disturbances underscores their importance in disease progression and positions them as high-value targets for biomarker development and therapeutic intervention. StressMarq's Alpha Synuclein Oligomer Antibody, clone 9D2, has demonstrated higher affinity to oligomers than to PFFs or monomers.
- Host:
- Mouse
- Immunogen:
- SPR-466 (Dopamine-stabilized alpha synuclein oligomers)
- Isotype:
- IgG1, kappa
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody demonstrates higher affinity to recombinant human oligomers over recombinant human PFFs and monomers.
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
