Dityrosine Antibody, Clone 7D4: ATTO 488
Product Sizes
100 ug
£602.00
SMC-520D-A488-100UG
About this Product
- SKU:
- SMC-520D-A488
- Additional Names:
- Dityrosine, Dityrosine (DT), DT, DY
- Application:
- ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 7D4
- Clonality:
- Monoclonal
- Conjugate:
- ATTO 488
- Concentration:
- 1 mg/ml
- Extra Details:
- Dityrosine is a stable, covalent cross-link formed between tyrosine residues in proteins under oxidative stress. It is generated by reactive oxygen species (ROS) such as hydroxyl radicals and catalyzed by peroxidases and UV radiation. As a biomarker of protein oxidation, dityrosine reflects cumulative oxidative damage in tissues. In the brain, elevated dityrosine levels are associated with protein aggregation, mitochondrial dysfunction, and neuroinflammation-features common to Alzheimer's, Parkinson's, and other neurodegenerative diseases. Monitoring dityrosine formation provides insight into oxidative stress burden and may aid in evaluating antioxidant therapies and disease progression in neurodegenerative research.
- Host:
- Mouse
- Immunogen:
- Synthetic Dityrosine conjugated to Keyhole Limpet Hemocyanin (KLH).
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Wide/Non-species Specific
- Shipping Conditions:
- Blue Ice
- Specificity:
- Specific for dityrosine modified proteins. Does not cross-react with 3,5-dibromotyrosine or bromotyrosine modified proteins.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
