Dicer Antibody, Clone N167/7
Product Sizes
12 ug
£111.00
SMC-416-12UG
100 ug
£447.00
SMC-416-100UG
About this Product
- SKU:
- SMC-416
- Additional Names:
- Dicer1, DCR, DCR1, DCR-1, Double-strand-specific ribonuclease, Helicase with RNase motif, HERNA, Helicase MOI, KIAA0928, Endoribonuclease Dicer
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- RUO
- translate.label.attr.clone:
- N167/7 (Formerly sold as S167-7)
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Dicer is a ribonuclease III enzyme essential for the biogenesis of microRNAs (miRNAs), which regulate gene expression post-transcriptionally. It processes precursor miRNAs into mature ~22-nucleotide miRNAs that guide the RNA-induced silencing complex (RISC) to target mRNAs. In the nervous system, Dicer is critical for neuronal differentiation, synaptic plasticity, and stress responses. Dysregulation of Dicer or miRNA pathways has been implicated in neurodegenerative diseases, including Alzheimer's, ALS, and Huntington's disease. Loss of Dicer function leads to widespread transcriptomic imbalance and neuronal vulnerability, making it a key player in epigenetic regulation and a potential therapeutic target in neurodegeneration.
- Host:
- Mouse
- Immunogen:
- Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~215kDa.
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/antibodies/monoclonal-antibodies/dicer-antibody-smc-416/
