ENaC beta Antibody, Clone 7B8: ATTO 488
Product Sizes
100 ug
SMC-240D-A488-100UG
About this Product
- SKU:
- SMC-240D-A488
- Additional Names:
- Amiloride sensitive sodium channel subunit beta, Amiloride-sensitive sodium channel beta-subunit, Beta ENaC, Beta NaCH, ENaC beta, ENaCB, Epithelial Na(+) channel subunit beta, Epithelial Na+ channel beta subunit, Epithelial Na+ channel subunit beta, Epithelial sodium channel beta 2 subunit, Epithelial sodium channel beta 3 subunit, Nonvoltage gated sodium channel 1 beta subunit, Nonvoltage gated sodium channel 1 subunit beta, Nonvoltage-gated sodium channel 1 beta subunit, SCNEB, SCNN 1B, SCNN1B, Sodium channel nonvoltage gated 1 beta, Sodium channel nonvoltage gated 1 beta (Liddle syndrome)
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 7B8
- Clonality:
- Monoclonal
- Conjugate:
- ATTO 488
- Concentration:
- 1 mg/ml
- Extra Details:
- The beta subunit of the epithelial sodium channel (ENaCB Beta) is essential for the functional assembly and regulation of the ENaC complex, which governs sodium absorption across epithelial surfaces. While ENaCB Beta is well-characterized in renal and pulmonary physiology, its emerging role in the nervous system is drawing increasing interest in neurodegenerative disease research. ENaCB Beta is critical for fluid clearance in distal lung epithelia, particularly in response to edema, and its expression is upregulated during keratinocyte differentiation-highlighting its involvement in cellular stress adaptation. In the retina, ENaCB Beta is differentially expressed under conditions of ocular hypertension, suggesting a role in neurovascular regulation and intraocular pressure homeostasis. These mechanisms are relevant to neurodegenerative diseases where fluid imbalance, oxidative stress, and ion dysregulation contribute to neuronal injury. Recent studies propose that ENaCB Beta may influence glial cell function, neuroinflammation, and blood-brain barrier integrity-key factors in the progression of disorders such as Parkinson's disease and ALS. As a regulator of sodium flux and tissue hydration, ENaCB Beta represents a promising target for modulating neuroimmune responses and preserving neural function. By bridging epithelial ion transport and neural health, ENaCB Beta offers a novel perspective in the search for biomarkers and therapeutic strategies in neurodegeneration.
- Host:
- Mouse
- Immunogen:
- Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638)
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~87kDa.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
