CENP-A Antibody, Clone 5A7-2E11
Product Sizes
12 ug
£111.00
SMC-202-12UG
100 ug
£419.00
SMC-202-100UG
About this Product
- SKU:
- SMC-202
- Additional Names:
- CENPA, CENP-A, Centromere autoantigen A, Histone H3-like centromeric protein A
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 5A7-2E11
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CENPA is a histone H3 variant that defines centromeric chromatin and is essential for kinetochore assembly and chromosome segregation. It replaces canonical H3 in centromeric nucleosomes and recruits key centromere proteins such as CENP-C. While primarily studied in mitotic cells, emerging research suggests that CENPA may also play roles in post-mitotic neurons by maintaining chromatin architecture and genome stability. Disruption of centromeric integrity and epigenetic regulation has been linked to neuronal aging and neurodegenerative diseases. CENPA's role in chromatin dynamics and nuclear organization positions it as a potential biomarker for genomic instability in neurodegeneration.
- Host:
- Mouse
- Immunogen:
- Synthetic peptide corresponding to a portion of human CENP-A
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~18kDa. Recognizes Human CENP-A.
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/antibodies/monoclonal-antibodies/cenp-a-antibody-smc-202/
