HIF-1 alpha Antibody, Clone ESEE122: HRP
Product Sizes
100 ug
£452.00
SMC-184D-HRP-100UG
About this Product
- SKU:
- SMC-184D-HRP
- Additional Names:
- ARNT interacting protein, HIF1A, Hypoxia inducible factor 1 alpha, MOP1, PASD8
- Application:
- ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- ESEE122
- Clonality:
- Monoclonal
- Conjugate:
- HRP
- Concentration:
- 1 mg/ml
- Extra Details:
- Hypoxia-inducible factor 1-alpha (HIF-1A Alpha) is a transcription factor that orchestrates cellular responses to low oxygen conditions. It regulates the expression of genes involved in angiogenesis, metabolism, and survival, making it a key player in adapting to hypoxic stress. In the brain, HIF-1A Alpha is activated under conditions of ischemia, inflammation, and mitochondrial dysfunction-hallmarks of many neurodegenerative diseases. Its activation promotes neuroprotective pathways, including increased glucose uptake, erythropoietin production, and vascular endothelial growth factor (VEGF) expression, which support neuronal survival and tissue repair. However, chronic or dysregulated HIF-1A Alpha signaling can contribute to pathological processes such as gliosis, blood-brain barrier disruption, and metabolic imbalance. In Alzheimer's and Parkinson's disease, altered HIF-1A Alpha activity has been linked to both protective and detrimental outcomes, depending on disease stage and cellular context. As a central regulator of the hypoxic response, HIF-1A Alpha represents a promising therapeutic target for modulating neuroinflammation, oxidative stress, and energy metabolism in neurodegenerative disorders.
- Host:
- Mouse
- Immunogen:
- Mouse recombinant fragment corresponding to amino acids 329-530
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Bovine, Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~116kDa. Specific for HIF1Alpha.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
