HDEL Antibody, Clone 2E7: ATTO 594
Product Sizes
100 ug
£522.00
SMC-175D-A594-100UG
About this Product
- SKU:
- SMC-175D-A594
- Additional Names:
- H-D-E-L (his-asp-glu-leu), endoplasmic reticulum, luminal ER protein retention, KDELR1, Endoplasmic reticulum retention signal
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- 2e7
- Clonality:
- Monoclonal
- Conjugate:
- ATTO 594
- Concentration:
- 1 mg/ml
- Extra Details:
- The HDEL sequence (His-Asp-Glu-Leu) is a C-terminal ER retention signal found in many soluble endoplasmic reticulum (ER) resident proteins. It plays a critical role in maintaining ER homeostasis by ensuring that chaperones and folding enzymes are retained or retrieved from the Golgi apparatus back to the ER. In neurodegenerative diseases, where ER stress and protein misfolding are prominent pathological features, the HDEL motif is essential for the proper localization and function of ER-resident proteins such as GRP78, GRP94, and protein disulfide isomerases. Disruption of HDEL-mediated retention can impair the unfolded protein response (UPR), exacerbate proteotoxic stress, and contribute to neuronal dysfunction. Moreover, the efficiency of the HDEL retrieval system may decline with age or under chronic stress, potentially leading to the mislocalization of protective chaperones and increased vulnerability to neurodegeneration. Understanding the dynamics of HDEL-mediated trafficking offers insights into ER stress regulation and may inform therapeutic strategies aimed at enhancing proteostasis in neurodegenerative disorders.
- Host:
- Mouse
- Immunogen:
- Raised against a synthetic HDEL peptide corresponding to the C-terminus of yeast Bip
- Isotype:
- IgG2b
- Purification:
- Protein G Purified
- Reactivities:
- Insect/Arthropod, Plant, Yeast/Fungi
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~78kDa.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
