KDEL Receptor Antibody, Clone KR-10: RPE
Product Sizes
100 ug
£486.00
SMC-129D-RPE-100UG
About this Product
- SKU:
- SMC-129D-RPE
- Additional Names:
- KDELR1, KDEL receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, ER lumen protein-retaining receptor 1, ERD2, ERD2.1, ERD21, KDEL R1, PM23, HDEL
- Application:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- CE/IVD:
- RUO
- translate.label.attr.clone:
- KR-10
- Clonality:
- Monoclonal
- Conjugate:
- R-PE
- Concentration:
- 1 mg/ml
- Extra Details:
- KDEL receptors are key components of the endoplasmic reticulum (ER) protein quality control system, essential for maintaining cellular homeostasis. These receptors recognize and retrieve ER-resident proteins bearing the KDEL (Lys-Asp-Glu-Leu) C-terminal motif, preventing their loss during vesicular transport to the Golgi apparatus. Variants of the KDEL sequence also contribute to ER retention, reflecting the system's adaptability. In mammalian cells, three highly conserved KDEL receptor isoforms are localized to the cis-Golgi and ER-Golgi intermediate compartments. Functionally, KDEL receptors interact with ARF1 GTPase-activating proteins (GAPs), facilitating COPI-dependent retrograde vesicle transport. This retrieval mechanism is critical for sustaining ER function, especially under conditions of proteotoxic stress. In the context of neurodegenerative diseases-such as Alzheimer's, Parkinson's, and ALS-chronic ER stress and impaired protein folding are central pathological features. Dysregulation of KDEL receptor function can disrupt the unfolded protein response (UPR), exacerbate protein misfolding, and contribute to neuronal dysfunction and degeneration. Moreover, the KDEL receptor shares significant sequence identity with the yeast Erd2p, underscoring its evolutionary conservation and fundamental role in ER homeostasis. As interest grows in targeting ER stress pathways for therapeutic intervention, the KDEL receptor is emerging as a promising molecular target in neurodegenerative disease research.
- Host:
- Mouse
- Immunogen:
- A 21 residue synthetic peptide (amino acids 192-212) based on the bovine KDEL receptor and the peptide coupled to KLH
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Amphibian, Avian, Bovine, Canine, Hamster, Human, Insect/Arthropod, Mouse, Non-human Primate, Porcine, Rabbit, Rat, Sheep
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~25kDa.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
