HSP90 alpha Antibody, Clone Hyb-K41009
Product Sizes
12 ug
£111.00
SMC-108-12UG
100 ug
£465.00
SMC-108-100UG
About this Product
- SKU:
- SMC-108
- Additional Names:
- HSP90AA1, HSP90-alpha, HSP90A, HSPCA, HSPC1, Heat shock protein HSP 90-alpha, Heat shock 90 kDa protein 1 alpha isoform, HSPCAL3, HSP86, HSP89A, HSP90Alpha
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- PBS pH7.2, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- Hyb-K41009
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- HSP90A Alpha is a cytosolic isoform of the highly conserved heat shock protein 90 (HSP90) family, which plays a central role in maintaining protein homeostasis under both normal and stress conditions. Although HSP90A Alpha and its isoform HSP90B Beta share 85% sequence identity, HSP90A Alpha predominantly forms homodimers and is more dynamically regulated in response to cellular stress. In the nervous system, HSP90A Alpha is essential for the folding, maturation, and stabilization of a wide range of client proteins, many of which are involved in synaptic signaling, neuronal survival, and stress response. These include kinases (e.g., c-Raf), transcription factors (e.g., p53), and hormone receptors-proteins that are often dysregulated in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. HSP90A Alpha functions as part of a multi-protein chaperone complex, interacting with co-chaperones like Cdc37 and p23. Upon ATP binding, HSP90A Alpha undergoes conformational changes that enable it to stabilize client proteins and prevent their degradation. However, in disease contexts, this protective mechanism can inadvertently preserve toxic protein species, contributing to pathogenesis. Pharmacological inhibition of HSP90A Alpha-using agents like geldanamycin-has shown promise in disrupting these pathogenic interactions and restoring proteostasis in neurodegenerative models.
- Host:
- Mouse
- Immunogen:
- Recombinant human HSP90alpha; Specificity mapped to amino acids 604-731
- Isotype:
- IgG2a
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects 90kDa. This is an alpha-specific product.
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/antibodies/monoclonal-antibodies/hsp90-alpha-antibody-smc-108/
