GRP94 Antibody, Clone 9G10
Product Sizes
12 ug
£111.00
SMC-105-12UG
200 ug
£406.00
SMC-105-200UG
About this Product
- SKU:
- SMC-105
- Additional Names:
- HSP90B1, GP96, TRA1, ECGP, 94 kDa glucose regulated protein, 94 kDa glucose-regulated protein, Endoplasmin, Endothelial cell (HBMEC) glycoprotein, ENPL_HUMAN, Glucose regulated protein 94kDa, gp96, gp96 homolog, GRP 94, GRP-94, Heat shock protein 90 kDa beta member 1, heat shock protein 90kDa beta (Grp94), member 1, Heat shock protein, 90 kDa, beta, 1, Stress inducible tumor rejection antigen GP96, tumor rejection antigen (gp96) 1, Tumor rejection antigen 1, Tumor rejection antigen gp96, Tumor rejection antigen-1 (gp96)
- Application:
- Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
- Buffer:
- PBS pH7.2, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 9G10
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- GRP94 (also known as gp96) is a constitutively expressed ER-resident chaperone and a member of the HSP90 family. It is upregulated in response to cellular stressors such as heat shock, oxidative damage, and glucose deprivation-conditions frequently observed in neurodegenerative diseases. Functionally, GRP94 supports protein translocation, folding, and quality control within the ER. It also plays a key role in immune regulation by facilitating antigen presentation through the MHC class I pathway, linking ER stress to immune responses. In the nervous system, GRP94 contributes to proteostasis and immune surveillance, both of which are disrupted in diseases like Alzheimer's and Parkinson's. Structurally, GRP94 forms homodimers and contains a KDEL sequence that ensures ER retention. Despite its homology with cytosolic HSP90, GRP94 exhibits distinct ATP-binding and hydrolysis characteristics, making it a unique therapeutic target. Its dual role in stress adaptation and immune signaling positions GRP94 as a valuable biomarker and potential intervention point in neurodegenerative disease research.
- Host:
- Rat
- Immunogen:
- Purified Grp94 isolated from chicken oviducts
- Isotype:
- IgG2a
- Purification:
- Protein G Purified
- Reactivities:
- Amphibian, Avian, Bovine, Canine, Guinea Pig, Hamster, Horse, Human, Mouse, Non-human Primate, Porcine, Rabbit, Rat, Sheep
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~98kDa. Does not detect human HSP90, Grp74, or GrpE from E.coli.
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/antibodies/monoclonal-antibodies/grp94-antibody-smc-105/
