Alpha-B Crystallin ELISA Kit
Product Sizes
96 wells
£909.00
SKT-123-96WELLS
About this Product
- SKU:
- SKT-123
- Additional Names:
- AACRYA, CRYA2, CRYAB, CTPP2, HSPB5, NY Ren 27 antigen, alpha crystallin B
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- Alpha B-crystallin (CRYAB) is a small heat shock protein originally identified as a structural component of the vertebrate eye lens. Beyond its role in maintaining lens transparency, CRYAB functions as a molecular chaperone, preventing protein aggregation under stress conditions. It shares structural and functional similarities with other small heat shock proteins such as HSP25 and HSP27. Importantly, alpha B-crystallin is expressed in a wide range of tissues, including the central nervous system, where it plays a critical role in cellular protection and protein homeostasis. In the brain, CRYAB is upregulated in response to oxidative stress, inflammation, and protein misfolding-hallmarks of neurodegenerative diseases. Emerging research highlights CRYAB's involvement in neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and Alexander disease. Its neuroprotective functions include inhibition of apoptosis via caspase suppression, stabilization of cytoskeletal elements, and interaction with key cellular components such as membrane proteins, nuclear proteins, and DNA. Due to its stress-inducible nature and anti-aggregation properties, alpha B-crystallin is increasingly recognized as a potential biomarker and therapeutic target in neurodegeneration. Its ability to modulate protein folding and prevent toxic aggregate formation positions it at the forefront of neuroscience research focused on proteinopathies.
- Format:
- Colorimetric
- Immunogen:
- Alpha-B Crystallin ELISA Kit
- Physical State:
- Cell Lysate, Serum, Tissue
- Range:
- 0.352 - 22.5 ng/ml
- Reactivities:
- Human
- Sensitivity:
- 0.009 ng/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C, -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Assay Kits: ELISAs
