DNA Damage (8-OHdG) ELISA Kit
Product Sizes
96 wells
SKT-120-96WELLS
About this Product
- SKU:
- SKT-120
- Additional Names:
- 8 hydroxyguanine, 8-OH-dG, 8-OHdG, 80G, 8OHG, DNA Damage
- CE/IVD:
- RUO
- Extra Details:
- 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a widely recognized biomarker of oxidative DNA damage, formed when reactive oxygen and nitrogen species modify guanine bases. This hydroxylation process occurs during normal metabolism and is amplified by environmental stressors that increase oxidative load. Elevated levels of 8-OHdG are strongly associated with aging and a range of chronic conditions, including cancer, diabetes, hypertension, and neurodegenerative diseases. In neuroscience, 8-OHdG serves as a critical indicator of oxidative stress in brain tissue, where neurons are particularly vulnerable due to high metabolic activity and lipid content. Increased 8-OHdG levels have been linked to the progression of Alzheimer's, Parkinson's, and other neurodegenerative disorders, making it a valuable tool for monitoring disease onset and therapeutic response. 8-OHdG can exist as a free nucleoside or be incorporated into DNA. In biological samples such as plasma, cell lysates, and tissues, its detection is complex; however, urine provides a more reliable matrix for measuring free 8-OHdG due to efficient renal filtration. Typical urinary concentrations range from 2.7-13 ng/mg creatinine, while plasma levels are significantly lower, often between 4-21 pg/mL as measured by LC-MS. By tracking 8-OHdG levels, researchers gain insight into cellular oxidative damage, enabling early detection and evaluation of antioxidant-based interventions in neurodegenerative disease research.
- Format:
- Colorimetric
- Immunogen:
- DNA Damage (8-OHdG) ELISA Kit
- Physical State:
- Cell Lysate, Plasma, Urine
- Range:
- 0.94 - 60 ng/mL
- Reactivities:
- Wide/Non-species Specific
- Sensitivity:
- 0.59 ng/mL
- Shipping Conditions:
- Blue Ice
- Specificity:
- Cross-reactivity: 8-Hydroxy-2-deoxy Guanosine (8-OHdG): 100%. 8-Hydroxy Guanosine (8-OHG): 23%. 8-Hydroxy Guanine (8-oxoG): 23%. Guanosine: <0.01%.
- Storage Conditions:
- 2-8[o]C, -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Assay Kits: ELISAs
