DNA Damage (8-OHdG) ELISA Kit
Product Sizes
96 wells
SKT-120-96WELLS
About this Product
- SKU:
- SKT-120
- Additional Names:
- 8-OH-dG ELISA Kit, 8OHG ELISA Kit, 80G ELISA Kit, 8 hydroxyguanine ELISA Kit, 8-OHdG ELISA Kit, DNA Damage ELISA Kit
- CE/IVD:
- RUO
- Extra Details:
- 8-hydroxy-2-deoxy Guanosine (8-OH-dG) is produced by the oxidative damage of DNA by reactive oxygen and nitrogen species and serves as an established marker of oxidative stress (1-4). Hydroxylation of guanosine occurs in response to both normal metabolic processes and a variety of environmental factors (i.e., anything that increases reactive oxygen and nitrogen species). Increased levels of 8-OH-dG are associated with the aging process as well as with a number of pathological conditions including cancer, diabetes, and hypertension(5-9). In complex samples such as plasma, cell lysates, and tissues, 8-OH-dG can exist as either the free nucleoside or incorporated in DNA. Once the blood enters the kidney, free 8-OH-dG is readily filtered into the urine, while larger DNA fragments remain in the bloodstream. Because of the complexity of plasma samples, urine is a more suitable matrix for the measurement of free 8-OH-dG than plasma. Urinary levels of 8-OH-dG range between 2.7-13 ng/mg creatine, while plasma levels of free 8-OH-dG have been reported to be between 4-21 pg/ml as determined by LC-MS (10-11).
- Format:
- Colorimetric
- Immunogen:
- DNA Damage (8-OHdG)
- Physical State:
- Cell Lysate, Plasma, Urine
- Range:
- 0.94 - 60 ng/mL
- Reactivities:
- Wide/Non-species Specific
- Sensitivity:
- 0.59 ng/mL
- Shipping Conditions:
- Blue Ice
- Specificity:
- Cross-reactivity: 8-Hydroxy-2-deoxy Guanosine (8-OHdG): 100%. 8-Hydroxy Guanosine (8-OHG): 23%. 8-Hydroxy Guanine (8-oxoG): 23%. Guanosine: <0.01%.
- Storage Conditions:
- 2-8[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Assay Kits: ELISAs
