HSP90 alpha ELISA Kit
Product Sizes
96 wells
£868.00
SKT-107-96WELLS
About this Product
- SKU:
- SKT-107
- Additional Names:
- HSP86, HSP89A, HSP90A, HSP90AA1, HSP90alpha, HSPC1, HSPCA, HsoCAL3
- CE/IVD:
- RUO
- Extra Details:
- Heat Shock Protein 90 (HSP90) is a highly conserved molecular chaperone essential for maintaining protein homeostasis across all eukaryotic cells. Although classified as a stress protein, HSP90 is abundantly expressed even under non-stress conditions, comprising up to 2% of cytosolic protein. Its core functions include the folding, maturation, stabilization, and trafficking of a wide range of client proteins. HSP90 plays a pivotal role in regulating key signaling molecules such as kinases (v-Src, Wee1, c-Raf), transcription factors (p53), steroid receptors, and enzymes like telomerase and viral polymerases. These interactions are mediated through ATP-dependent conformational changes and co-chaperone complexes involving Cdc37, p23, and immunophilin-like proteins, which protect client proteins from proteasomal degradation. In neuroscience, HSP90 is increasingly recognized for its role in modulating protein misfolding and aggregation-central features of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Alterations in HSP90 expression or function can disrupt neuronal signaling and impair the activity of neuroprotective proteins, contributing to disease progression. Pharmacological inhibitors of HSP90, including geldanamycin and radicicol, are being explored as therapeutic agents to restore proteostasis and reduce toxic protein accumulation in neurodegenerative models.
- Format:
- Colorimetric
- Immunogen:
- HSP90 alpha ELISA Kit
- Physical State:
- Blood, Cell Lysate, Serum, Tissue
- Range:
- 0.44 - 28 ng/ml
- Reactivities:
- Avian, Goat, Human
- Sensitivity:
- 0.117 ng/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C, -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Assay Kits: ELISAs
