Olesoxime
Product Sizes
5 mg
£164.00
SIH-644-5MG
25 mg
£428.00
SIH-644-25MG
About this Product
- SKU:
- SIH-644
- Additional Names:
- TRO 19622; Cholest-4-en-3-one oxime
- CAS Number:
- 22033-87-0
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- Olesoxime is a neuroregenerative and neuroprotective agent that acts on components of the mitochondrial permeability transition pore (mPTP). It rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Olesoxime inhibits mPTP opening, protects neurons from apoptosis, and reduces reactive oxygen species production and NLRP3 inflammasome activation in models of intracerebral hemorrhage. It also induces oligodendrocyte maturation in vitro and promotes myelin regeneration in rodent models. In preclinical neuroscience studies, olesoxime has been shown to improve cerebral mitochondrial dysfunction and modulate amyloid-B Beta pathology in models of Alzheimer's disease. Reviews of olesoxime across neurodegenerative disease models highlight its potential as a therapeutic candidate due to its ability to stabilize mitochondrial function and enhance neuronal survival.
- Molecular Weight:
- 399.7
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/neuroprotective-agent/olesoxime-sih-644/
