T0901317
Product Sizes
10 mg
£208.00
SIH-643-10MG
50 mg
£455.00
SIH-643-50MG
About this Product
- SKU:
- SIH-643
- Additional Names:
- N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
- CAS Number:
- 293754-55-9
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- T0901317 is a potent, high-affinity agonist of liver X receptors LXRA Alpha and LXRB Beta (EC₅₀ ~ 50 nM). Of particular relevance to neuroscience, T0901317 has been shown to decrease amyloid-B Beta production in a mouse model of Alzheimer's disease, highlighting its potential utility in neurodegenerative disease research. This effect is thought to be mediated, at least in part, through upregulation of ABCA1, a key reverse cholesterol transporter implicated in brain lipid homeostasis and amyloid processing. Beyond its central nervous system effects, T0901317 inhibits intestinal cholesterol absorption via ABCA1 induction and acts as an inverse agonist at CAR2. The compound has also been reported to inhibit cellular senescence in endothelial cells. Notably, T0901317 displays off-target activity as an FXR agonist, albeit at lower potency than LXR, necessitating the use of appropriate experimental controls when employing this compound as a pharmacological tool.
- Molecular Weight:
- 481.3
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/regulator/t0901317-sih-643/
