Tyrphostin 9
Product Sizes
10 mg
£136.00
SIH-641-10MG
25 mg
£246.00
SIH-641-25MG
About this Product
- SKU:
- SIH-641
- Additional Names:
- 3,5-Di-tert-butyl-4-hydroxybenzylidene-malononitrile; Tyrphostin A9; Malonoben; AG-17; SF 6847; RG-50872
- CAS Number:
- 10537-47-0
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- Tyrphostin A9 is a well-characterized inhibitor of PDGF receptor tyrosine kinase, exhibiting an IC₅₀ of 1.2uM. It also functions as a potent inhibitor of oxidative phosphorylation at nanomolar concentrations (10nM). Beyond its primary kinase-related effects, Tyrphostin A9 suppresses cellular proliferation by disrupting mitochondrial integrity and perturbing Golgi complex organization. These actions collectively contribute to its ability to block the growth of vascular smooth muscle cells. Of particular relevance to neuroscience, Tyrphostin A9 has been shown to induce mild mitochondrial uncoupling in midbrain dopaminergic (mDA) neurons. This mitochondrial modulation is associated with a reduction in intracellular A Alpha-synuclein levels, suggesting a potential therapeutic angle for disorders characterized by A Alpha-synuclein accumulation.
- Molecular Weight:
- 282.4
- Purity:
- >99%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/tyrosine-kinase-inhibitor/tyrphostin-9-sih-641/
