1-Deoxynojirimycin
Product Sizes
10 mg
SIH-547-10MG
50 mg
SIH-547-50MG
About this Product
- SKU:
- SIH-547
- Additional Names:
- 1-deoxymannojirimycin, 1-DEOXYNOJIRIMYCIN, 19130-96-2, DUVOGLUSTAT, (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, Moranoline, Deoxynojirimycin
- CAS Number:
- 19130-96-2
- CE/IVD:
- RUO
- Extra Details:
- 1-Deoxynojirimycin (DNJ) is a naturally occurring iminosugar best known for its potent inhibition of A Alpha-glucosidases, enzymes critical to glycoprotein processing and carbohydrate metabolism. While DNJ has been extensively studied in the context of metabolic disorders such as diabetes and lysosomal storage diseases, its relevance to neuroscience is gaining attention. In neurodegenerative disease research, DNJ's ability to modulate glycosphingolipid metabolism positions it as a promising candidate for targeting pathological protein aggregation and lysosomal dysfunction-hallmarks of disorders like Parkinson's and Gaucher disease. Recent studies suggest that DNJ and its derivatives may influence neuroinflammatory pathways and neuronal survival by altering glycan processing, potentially mitigating neurodegeneration. Its role in modulating endoplasmic reticulum stress and autophagy further underscores its therapeutic potential in neurodegenerative contexts. Additionally, DNJ's capacity to cross the blood-brain barrier enhances its appeal for central nervous system applications. Beyond neuroscience, DNJ remains a cornerstone compound in glycobiology and antiviral research, particularly for its ability to interfere with viral glycoprotein maturation.
- Molecular Weight:
- 163.2
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/1-deoxynojirimycin-sih-547/
