SB203580
Product Sizes
5 mg
£291.00
SIH-474-5MG
25 mg
£951.00
SIH-474-25MG
About this Product
- SKU:
- SIH-474
- Additional Names:
- 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
- CAS Number:
- 152121-47-6
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- SB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAP kinase, particularly the p38A Alpha isoform. It also inhibits phosphorylation of heat shock protein 27 (HSP27) and can activate Raf-1 signaling. In neuroscience, SB203580 is used to study the role of p38 MAPK in neuroinflammation, synaptic plasticity, and neuronal survival. Its high selectivity over kinases such as LCK, GSK-3B Beta, and PKBA Alpha makes it a reliable tool for dissecting p38-mediated signaling in neurodegenerative disease models. SB203580 is cell-permeable and is frequently employed in studies of Alzheimer's disease, stroke, and other CNS disorders involving inflammatory and stress responses.
- Molecular Weight:
- 377.4
- Purity:
- ≥98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/sb203580-sih-474/
