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Proteins and Peptides

AS 041164

Product Sizes
10 mg
SIH-433-10MG
50 mg
SIH-433-50MG
About this Product
SKU:
SIH-433
Additional Names:
NSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione
CAS Number:
6318-41-8
CE/IVD:
RUO
Extra Details:
AS 041164 is a selective inhibitor of the PI3KG Gamma isoform, a key regulator of immune cell signaling and migration. In neuroscience, PI3KG Gamma has been implicated in neuroinflammatory responses and microglial activation, processes that contribute to the progression of neurodegenerative diseases. By blocking PI3KG Gamma activity, AS 041164 can modulate leukocyte trafficking and reduce neuroinflammation, making it a valuable tool for studying immune-mediated mechanisms in conditions such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. Its ability to inhibit neutrophil migration further supports its application in models of neurovascular inflammation and blood-brain barrier dysfunction.
Molecular Weight:
249.2
Purity:
≥98%
Shipping Conditions:
Ambient
Source:
Synthetic
Storage Conditions:
-20[o]C
Supplier:
StressMarq Biosciences
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
Chemical structure of AS 041164 (SIH-433), a PI 3-Kgamma kinase inhibitor. CAS #: 6318-41-8. Molecular Formula: C11H7NO4S. Molecular Weight: 249.2 g/mol.