6BIO
Product Sizes
5 mg
£159.00
SIH-422-5MG
25 mg
£448.00
SIH-422-25MG
About this Product
- SKU:
- SIH-422
- Additional Names:
- (2'Z,3'E)-6-Bromoindirubin-3'-oxime, 6-BIO, 6BIO, (3Z)-6-Bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
- CAS Number:
- 667463-62-9
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- 6BIO is a potent, reversible, and ATP-competitive inhibitor of glycogen synthase kinase-3A Alpha/B Beta (GSK-3A Alpha/B Beta), as well as an inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Its ability to modulate the Wnt signaling pathway has made it a valuable tool in stem cell biology, particularly for maintaining self-renewal and pluripotency in embryonic stem cells. Although its primary applications have been in developmental biology and cancer research, emerging evidence suggests that GSK-3 inhibition may have neuroprotective effects. In the context of neurodegenerative diseases, 6BIO's modulation of GSK-3 activity could influence tau phosphorylation and amyloid precursor protein processing, both of which are implicated in Alzheimer's disease. This positions 6BIO as a compound of growing interest in neuroscience, particularly for its potential to modulate key signaling pathways involved in neuronal survival and plasticity.
- Molecular Weight:
- 356.2
- Purity:
- ≥98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/6bio-sih-422/
