Bafilomycin A1
Product Sizes
100 ug
£125.00
SIH-391-100UG
500 ug
£191.00
SIH-391-500UG
About this Product
- SKU:
- SIH-391
- Additional Names:
- (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
- CAS Number:
- 88899-55-2
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- Bafilomycin A1 is a macrolide antibiotic that selectively inhibits vacuolar-type H⁺-ATPases (V-ATPases), disrupting lysosomal acidification and autophagic flux. In neuroscience, Bafilomycin A1 is widely used to study autophagy, a critical process for neuronal health and protein clearance. By blocking autophagosome-lysosome fusion or lysosomal degradation, Bafilomycin A1 allows researchers to assess autophagic activity and flux in neuronal cells. Impaired autophagy is a common feature in neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. Bafilomycin A1 is instrumental in elucidating the role of lysosomal dysfunction in these conditions and in evaluating therapeutic strategies aimed at restoring autophagic balance.
- Molecular Weight:
- 622.84
- Purity:
- >98% HPLC; NMR (Conforms)
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/bafilomycin-a1-sih-391/
