Doxorubicin Hydrochloride
Product Sizes
10 mg
£211.00
SIH-390-10MG
50 mg
£606.00
SIH-390-50MG
About this Product
- SKU:
- SIH-390
- Additional Names:
- Adriamycin
- CAS Number:
- 25316-40-9
- CE/IVD:
- RUO
- Extra Details:
- Doxorubicin Hydrochloride is a DNA-intercalating chemotherapeutic agent known for its broad-spectrum anticancer activity. In neuroscience, Doxorubicin is used to model neurotoxicity and investigate mechanisms of neuronal damage, particularly in studies of chemotherapy-induced cognitive impairment ("chemo brain"). It induces apoptosis by inhibiting topoisomerase II and disrupting DNA replication and transcription. Doxorubicin also triggers oxidative stress and mitochondrial dysfunction-key features of neurodegenerative diseases. Although its clinical use is limited by systemic toxicity, including hematologic and cardiac effects, its ability to induce autophagy and cell death pathways makes it a valuable tool for studying neuronal stress responses and neurodegeneration in vitro and in vivo.
- Molecular Weight:
- 580
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inducer/doxorubicin-hydrochloride-sih-390/
