Rosiglitazone Maleate
Product Sizes
10 mg
£125.00
SIH-379-10MG
50 mg
£312.00
SIH-379-50MG
About this Product
- SKU:
- SIH-379
- Additional Names:
- 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
- CAS Number:
- 155141-29-0
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- Rosiglitazone Maleate is a high-affinity agonist of peroxisome proliferator-activated receptor gamma (PPARG Gamma), with an EC50 of 43 nM. While primarily developed as an insulin sensitizer for type 2 diabetes, Rosiglitazone has gained attention in neurodegenerative disease research, particularly Alzheimer's disease. Activation of PPARG Gamma has been shown to modulate neuroinflammation, enhance mitochondrial function, and improve insulin signaling in the brain-factors implicated in cognitive decline. Rosiglitazone has demonstrated the ability to rescue memory deficits in preclinical Alzheimer's models, positioning it as a candidate for therapeutic repurposing. Its dual role in metabolic regulation and neuroprotection makes it a valuable compound in the study of neurodegeneration and brain insulin resistance.
- Molecular Weight:
- 473.5
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/agonist/rosiglitazone-maleate-sih-379/
