DAPT
Product Sizes
5 mg
£166.00
SIH-378-5MG
25 mg
£452.00
SIH-378-25MG
About this Product
- SKU:
- SIH-378
- Additional Names:
- N-[(3,5-Difluorophenyl)acetyl]-L-al-anyl-2-phenyl]glycine-1,1-dimethylethyl ester
- CAS Number:
- 208255-80-5
- CE/IVD:
- RUO
- Extra Details:
- DAPT is a potent G Gamma-secretase inhibitor widely used in neuroscience and neurodegenerative disease research. By selectively reducing the production of amyloid-B Beta peptides AB Beta40 and AB Beta42-key contributors to Alzheimer's disease pathology-DAPT serves as a critical tool for studying amyloidogenic processing of amyloid precursor protein (APP). It effectively lowers AB Beta levels in human primary neuronal cultures and in vivo models, including brain, cerebrospinal fluid, and plasma, without altering non-amyloidogenic APPA Alpha and APPB Beta fragments. DAPT also inhibits Notch signaling, a pathway implicated in neural development and cell fate decisions. Its ability to promote neuronal differentiation makes it valuable for exploring neurogenesis and neural stem cell biology. DAPT is frequently cited in studies investigating the molecular mechanisms of Alzheimer's disease, neuroinflammation, and synaptic dysfunction.
- Molecular Weight:
- 432.46
- Purity:
- >99%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/dapt-sih-378/
