EX-527
Product Sizes
5 mg
£175.00
SIH-353-5MG
25 mg
£521.00
SIH-353-25MG
About this Product
- SKU:
- SIH-353
- Additional Names:
- 6-Chloro-2,3,4,9-tetrahydro-1Hcarbazole-1-carboxamide (racemic)
- CAS Number:
- 49843-98-3
- CE/IVD:
- RUO
- Extra Details:
- EX-527 is a potent and selective SIRT1 inhibitor (IC₅₀ = 98 nM) that does not affect other sirtuins or HDACs. It increases p53 acetylation following DNA damage and is fully cell permeable. In neuroscience, EX-527 has been shown to promote neuronal differentiation from pluripotent stem cells and modulate neurogenesis-related transcription factors. Its ability to influence cell fate decisions and epigenetic plasticity makes it a valuable probe for studying neurodevelopment, cellular reprogramming, and SIRT1-linked pathways in neurodegenerative disease models.
- Molecular Weight:
- 248.7
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/ex-527-sih-353/
