Nutlin-3
Product Sizes
5 mg
£255.00
SIH-344-5MG
25 mg
£759.00
SIH-344-25MG
About this Product
- SKU:
- SIH-344
- Additional Names:
- (+/-)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one
- CAS Number:
- 548472-68-0
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Extra Details:
- Nutlin-3 is a potent and selective antagonist of MDM2 that inhibits the MDM2-p53 interaction (IC50 = 0.09 uM), leading to p53 stabilization and activation. It induces apoptosis and cell cycle arrest in cancer cells and has been widely used to study p53 signaling. In neuroscience, Nutlin-3 is of interest for its ability to modulate p53-dependent pathways involved in neuronal stress responses, DNA repair, and apoptosis. Its neuroprotective potential is being explored in models of stroke, neuroinflammation, and neurodegenerative diseases where p53 dysregulation contributes to pathology.
- Molecular Weight:
- 581.9
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/nutlin-3-sih-344/
