YM-01

Product Sizes

10 mg

£276.00

SIH-121-10MG

25 mg

£495.00

SIH-121-25MG

About this Product

SKU:: SIH-121
Additional Names:: 2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride; YM-1
CAS Number:: 409086-68-6
CE/IVD:: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Extra Details:: YM-01 is an allosteric inhibitor of Hsp70 that binds within its nucleotide-binding domain, adjacent to the ATP/ADP pocket. It disrupts Hsc70-Bag1 interactions and enhances Hsp70 binding to misfolded proteins. In neuroscience, YM-01 has shown efficacy in reducing tau protein levels in cellular and animal models of tauopathy, including Alzheimer's disease. It restores long-term potentiation in brain slices from tau-overexpressing mice, indicating potential for cognitive recovery. YM-01's dual activity in protein quality control and synaptic function makes it a valuable tool for studying and potentially treating tau-related neurodegenerative disorders.
Molecular Weight:: 417.97
Purity:: >98%
Shipping Conditions:: Ambient
Source:: Synthetic
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors

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