17-DMAG
Product Sizes
1 mg
SIH-114-1MG
5 mg
SIH-114-5MG
About this Product
- SKU:
- SIH-114
- Additional Names:
- Alvespimycin, 17DMAG, 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin, 17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin, 17-DMAG, 17-Dimethylaminoethylamino, 17-Demethoxygeldanamycin, [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-21-[2-(dimethylamino)ethylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- CAS Number:
- 467214-20-6
- CE/IVD:
- RUO
- Extra Details:
- 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin) is a water-soluble, bioavailable analog of geldanamycin and 17-AAG, designed to overcome the solubility and toxicity limitations of its predecessors. As a high-affinity HSP90 inhibitor, 17-DMAG disrupts the stability of client proteins involved in neurodegenerative disease pathways. Preclinical studies highlight its ability to induce autophagy and promote the clearance of alpha-synuclein aggregates, a hallmark of Parkinson's disease and related disorders. Its favorable pharmacokinetic profile, including efficient tissue distribution and reduced metabolic degradation, makes 17-DMAG a compelling candidate for CNS-targeted therapies. By enhancing proteostasis and mitigating protein aggregation, 17-DMAG represents a promising tool for modulating neurodegenerative processes at the molecular chaperone level.
- Molecular Weight:
- 616.8
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/small-molecules/inhibitor/17-dmag-sih-114/
