IL-6 receptor alpha, soluble
Product Sizes
5 ug
£178.82
S01-045-5UG
20 ug
£307.06
S01-045-20UG
About this Product
- SKU:
- S01-045
- Additional Names:
- Il6r; CD126; IL-6R
- translate.label.attr.clone:
- Goat IgG
- Extra Details:
- IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6RA Alpha and gp130. While the IL-6RA Alpha chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6RA Alpha. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6RA Alpha alone. IL-6RA Alpha is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6RA Alpha, which consists of only the extracellular domain of the IL-6RA Alpha chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant Human sIL-6 Receptor A Alpha is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6RA Alpha. As a result of glycosylation, Recombinant Human sIL-6 Receptor A Alpha migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions.
- Formulation:
- lyophilized
- Host:
- E. coli
- Molecular Weight:
- 37.9 kDa
- Purity:
- > 95% by SDS-PAGE & HPLC analyses
- Reactivities:
- Human, Mouse, Rat
- Sequence:
- LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins