IL-21
Product Sizes
2 ug
£178.82
R20-036-2UG
10 ug
£307.06
R20-036-10UG
About this Product
- SKU:
- R20-036
- Additional Names:
- IL21, Interleukin-21
- Extra Details:
- IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naive B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the G Gamma chain (G Gammac) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Rat IL-21 is a 15.3 kDa protein containing 130 amino acid residues.
- Formulation:
- lyophilized
- Host:
- E. coli
- Molecular Weight:
- 15.3 kda
- Purity:
- ≥98%
- Reactivities:
- Rat
- Sequence:
- MHKSSPQRPD HLLIRLRHLM DIVEQLKIYE NDLDPELLTA PQDVKGQCEH EAFACFQKAK LKPSNTGNNK TFINDLLAQL RRRLPAKRTG NKQRHMAKCP SCDLYEKKTP KEFLERLKWL LQKMIHQHLS
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins