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Antibodies

VEGFR-1/Flt-1, Antagonistic

Product Sizes
100 ug
£976.47
MV1004-1M-H-M-100UG
About this Product
SKU:
MV1004-1M-H-M
Additional Names:
vascular endothelial growth factor receptor-1; FLT1; FLT; VEGF receptor 1
Application:
Block/Inhibit/Neutralise, Western Blot
Buffer:
PBS
translate.label.attr.clone:
MAB0702
Clonality:
Monoclonal
Extra Details:
Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVEC supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA. The antibody will bind near the ligand binding site of the receptor and has antagonistic activity by blocking the binding of natural ligands.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant hVEGFR1 extracellular domain
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human, Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody