R-Spondin 2 / FTLS / RSPO2 Protein (mFc Tag)
Product Sizes
50 ug
£447.00
M60-150-L50-50UG
About this Product
- SKU:
- M60-150-L50
- Additional Names:
- 2610028F08Rik Protein; D430027K22 Protein; ftls Protein; Rspo2 Protein
- Buffer:
- PBS
- Extra Details:
- R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.
- Formulation:
- lyophilized
- Molecular Weight:
- 47 kDa
- Purity:
- >95%
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
