R-Spondin 1 / RSPO1 Protein (His Tag)
Product Sizes
100 ug
£600.00
M60-149-L100-100UG
About this Product
- SKU:
- M60-149-L100
- Additional Names:
- R-spondin Protein; Rspo1 Protein; Rspondin Protein
- Buffer:
- PBS
- Extra Details:
- RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.
- Formulation:
- lyophilized
- Molecular Weight:
- 44 kDa (glycosylated)
- Purity:
- >95%
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
