IL-28B / IFN-lambda-3 Protein (His Tag)
Product Sizes
50 ug
£447.00
M60-117-L50-50UG
About this Product
- SKU:
- M60-117-L50
- Additional Names:
- If1ia2 Protein; IFL-1 Protein; Ifnl3 Protein; IL-28B Protein; Il28 Protein; Il28b Protein; INF-alpha Protein; INF-lambda Protein
- Buffer:
- PBS
- Extra Details:
- Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNL Lambda) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, can increase the percentage of splenic CD8+ T cells in vaccinated animals and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.
- Formulation:
- lyophilized
- Molecular Weight:
- 21 kDa
- Purity:
- >95%
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
