ICOS Ligand / B7-H2 / ICOSLG Protein (His & Fc Tag)
Product Sizes
100 ug
£447.00
M60-108-L100-100UG
About this Product
- SKU:
- M60-108-L100
- Additional Names:
- B7-H2 Protein; B7h Protein; B7H2 Protein; B7RP-1 Protein; B7RP1 Protein; CD275 Protein; GL50 Protein; ICOS-L Protein; ICOSL Protein; IMD119 Protein; KIAA0653 Protein; LICOS Protein
- Buffer:
- PBS
- Extra Details:
- Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.
- Formulation:
- lyophilized
- Molecular Weight:
- 80 kDa (glycosylated)
- Purity:
- >95%
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
