Wnt-3a
Product Sizes
10 ug
£270.59
M30-231-10UG
20 ug
£411.76
M30-231-20UG
About this Product
- SKU:
- M30-231
- Additional Names:
- Wingless-type MMTV (mouse mammary tumor virus) integration site family member 3a
- Extra Details:
- Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System (CNS). Wnt-3a signaling is essential for various morphogenetic events, including embryonic patterning, cell determination, cell proliferation, CNS development, and cytoskeletal formation. Like other members of this family, Wnt-3a contains a highly conserved lipid-modified, cysteine-rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway, Wnt family members bind to and activate, seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of B Beta-catenin degradation. Intracellular accumulation of B Beta-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant Murine Wnt-3a is a monomeric glycoprotein containing 334 amino acid residues.
- Formulation:
- lyophilized
- Purity:
- > 85% by SDS-PAGE & Coomassie Stain
- Reactivities:
- Mouse
- Sequence:
- MSYPIWWSLA VGPQYSSLST QPILCASIPG LVPKQLRFCR NYVEIMPSVA EGVKAGIQEC QHQFRGRRWN CTTVSNSLAI FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGSAAICG CSSRLQGSPG EGWKWGGCSE DIEFGGMVSR EFADARENRP DARSAMNRHN NEAGRQAIAS HMHLKCKCHG LSGSCEVKTC WWSQPDFRTI GDFLKDKYDS ASEMVVEKHR ESRGWVETLR PRYTYFKVPT ERDLVYYEAS PNFCEPNPET GSFGTRDRTC NVSSHGIDGC DLLCCGRGHN ARTERRREKC HCVFHWCCYV SCQECTRVYD VHTCKLEHHH HHH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins