Flt-3 Ligand
Product Sizes
2 ug
£178.82
M10-062-2UG
10 ug
£307.06
M10-062-10UG
About this Product
- SKU:
- M10-062
- Additional Names:
- Flt3; Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04
- Extra Details:
- Flt3 Ligand, also known as FL, is an A Alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. Mature mouse Flt3 Ligand consists of a 161 amino acid (aa) extracellular domain (ECD) with a cytokinelike domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 22 aa cytoplasmic tail. Within the ECD, mouse Flt3 Ligand shares 71% and 81% aa sequence identity with human and rat Flt3 Ligand, respectively. Mouse and human Flt3 Ligand show cross-species activity. Flt3 Ligand is expressed as a non-covalently-linked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O-linked carbohydrates. Alternate splicing and proteolytic cleavage of the transmembrane form can generate a soluble 30 kDa fragment that includes the cytokine domain. Alternate splicing of mouse Flt3 Ligand also generates a membrane-associated isoform with a 57 aa substitution following the cytokine domain. Both transmembrane and soluble Flt3 Ligand signal through the tyrosine kinase receptor Flt3/ Flk2.
- Formulation:
- lyophilized
- Host:
- E. coli
- Molecular Weight:
- 18.6 kDa
- Purity:
- > 98% by SDS-PAGE & HPLC analyses
- Reactivities:
- Human, Mouse, Rat
- Sequence:
- MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQ
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins