TRAIL R2 / CD262 / TNFRSF10B Protein (hFc Tag)
Product Sizes
100 ug
£447.00
600-268-L100-100UG
About this Product
- SKU:
- 600-268-L100
- Additional Names:
- CD262 Protein; DR5 Protein; KILLER Protein; KILLER/DR5 Protein; TRAIL-R2 Protein; TRAILR2 Protein; TRICK2 Protein; TRICK2A Protein; TRICK2B Protein; TRICKB Protein; UNQ160/PRO186 Protein; ZTNFR9 Protein
- Buffer:
- PBS
- Extra Details:
- Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.
- Formulation:
- lyophilized
- Molecular Weight:
- 41 kDa
- Purity:
- ≥95%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
