Human TIMP2 / TIMP-2 Protein (hFc Tag)
Product Sizes
20 ug
£341.00
600-261-L20-20UG
About this Product
- SKU:
- 600-261-L20
- Additional Names:
- CSC-21K Protein; DDC8 Protein
- Buffer:
- 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
- Extra Details:
- Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment.
- Formulation:
- lyophilized
- Molecular Weight:
- 48 kDa
- Purity:
- ≥ 90 % as determined by SDS-PAGE
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
