SerpinF1 / PEDF Protein (His Tag)
Product Sizes
50 ug
£388.00
600-240-L50-50UG
About this Product
- SKU:
- 600-240-L50
- Additional Names:
- EPC-1 Protein; OI12 Protein; OI6 Protein; PEDF Protein; PIG35 Protein; SERPINF1 Protein
- Buffer:
- PBS
- Extra Details:
- Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
- Formulation:
- lyophilized
- Molecular Weight:
- 46 kDa
- Purity:
- ≥ 98 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
