R-Spondin 2/RSPO2 Protein (hFc Tag)
Product Sizes
100 ug
£612.00
600-229-L100-100UG
About this Product
- SKU:
- 600-229-L100
- Additional Names:
- CRISTIN2 Protein; HHRRD Protein; MGC35555 Protein; TETAMS2 Protein; UNQ9384/PRO34209 Protein
- Buffer:
- Histidine, Arginine, 120mM NaCl, 0.02% Tween 80, 5% sucrose, pH 6.0.
- Extra Details:
- R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.
- Formulation:
- lyophilized
- Molecular Weight:
- 56 kDa (glycosylated)
- Purity:
- >90%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
