R-Spondin 1 / RSPO1 Protein (aa 1-146, His Tag)
Product Sizes
1000 ug
£2812.00
600-228-L1000-1000UG
About this Product
- SKU:
- 600-228-L1000
- Additional Names:
- CRISTIN3 Protein; FLJ40906 Protein; RSPO Protein; RSPONDIN Protein
- Buffer:
- PBS
- Extra Details:
- RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.
- Formulation:
- lyophilized or frozen liquid
- Molecular Weight:
- 23 kDa (glycosylated)
- Purity:
- >98%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
