PD-L1 / B7-H1 / CD274 Protein (ECD, mFc Tag)
Product Sizes
100 ug
£400.00
600-051-L100-100UG
About this Product
- SKU:
- 600-051-L100
- Additional Names:
- B7-H Protein; B7-H1 Protein; B7H1 Protein; hPD-L1 Protein; PD-L1 Protein; PDCD1L1 Protein; PDCD1LG1 Protein; PDL1 Protein
- Buffer:
- 20 mM Tris, 150 mM NaCl, 10 % Glycerol, pH 8.5.
- Extra Details:
- Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
- Formulation:
- lyophilized
- Molecular Weight:
- 66 kDa (glycosylated)
- Purity:
- ≥95%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
