CCL26 / Eotaxin-3 Protein
Product Sizes
20 ug
£353.00
600-038-L20-20UG
About this Product
- SKU:
- 600-038-L20
- Additional Names:
- eotaxin-3 Protein; IMAC Protein; MIP-4a Protein; MIP-4alpha Protein; SCYA26 Protein; TSC-1 Protein; UNQ216/PRO242 Protein
- Buffer:
- 20 mM Tris, 300 mM NaCl, 10 % Glycerol, pH 8.0
- Extra Details:
- The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3), which is also expressed by several different cell types, including basophils, dendritic cells, smooth muscle cells, epithelial cells and fibroblasts. The sequence similarity between the three eotaxins is limited (<4%), but their functional properties are very similar. Eotaxin-1 and -2 are expressed by both haematopoietic and non-haematopoietic cells, but eotaxin-3 expression has been reported to be limited to non-haematopoietic cells. Interleukin (IL)-4 is the main inducer for eotaxin-3 expression, whereas eotaxin-1 is up-regulated by IL-4 and the proinflammatory cytokine tumour necrosis factor (TNF)-A Alpha. Eotaxin-3 is expressed in vascular endothelial cells and human dermal fibroblasts after IL-4 and IL-13 stimulation, and this is dependent upon the IL-4-/IL-13-specific transcription factor, signal transducers and activator of transcription (STAT)-6. Eotaxin-3 is expressed on the surface of IL-4-stimulated endothelial cells and promotes eosinophil transmigration.
- Formulation:
- lyophilized
- Molecular Weight:
- 8.4 kDa
- Purity:
- >95%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
