GM-CSF
Product Sizes
2 ug
£147.06
400-010-2UG
5 ug
£204.71
400-010-5UG
About this Product
- SKU:
- 400-010
- Additional Names:
- CSF2; GMCSF
- Buffer:
- PBS
- Extra Details:
- Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), a 14,6 kDa protein consisting of 127 amino acid residues (Ala18-Glu144) and fused to a C-terminal His-tag (6x His), is a potent species specific stimulator of bone marrow cells and several other cell types. GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages and eosinophils. GM-CSF has also been reported to have a functional role on non-hematopoietic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. GM-CSF is species specific and human GM-CSF has no biological effects on mouse cells. GM-CSF exerts its biological effects through binding to specific cell surface receptors. The high affinity receptors required for human GM-CSF signal transduction have been shown to be heterodimers consisting of a GM-CSF-specific A Alpha chain and a common B Beta chain that is shared by the high-affinity receptors for IL-3 and IL-5.
- Formulation:
- lyophilized (freeze-dried)
- Host:
- E. coli
- Molecular Weight:
- ~15-18 kDa
- Purity:
- >98%
- Reactivities:
- Human
- Sequence:
- APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQETRHHHHHH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C dessicated. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins