Gremlin-1
Product Sizes
100 ug
£270.59
103-PA46-100UG
200 ug
£411.76
103-PA46-200UG
About this Product
- SKU:
- 103-PA46
- Additional Names:
- Grem1; ld; Drm; Cktsf1b1
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- (#6G14)
- Clonality:
- Polyclonal
- Extra Details:
- Gremlin, also known as "Increased in High Glucose protein 2" (IHG2) and "Down regulated in Mos-transformed cells protein" (Drm), is a 28 kDa member of the Dan family of secreted glycoproteins. Native human Gremlin consist of 160 amino acids. The mature region contains one potential site for N-linked glycosylation (Asn42), a cysteine-rich region, and a cysteine-knot motif (aa94-184) whose structure is shared by members of the TGFB Beta superfamily. Posttranslational modifications include glycosylation and phosphorylation. Human Gremlin exists in both secreted and membrane-associated forms and there exist 2 isoforms. The aa sequence identity of human Gremlin with mouse and chicken Gremlin is 99% and 86%, respectively. Northern blot analysis shows that Gremlin mRNA is highly expressed in the small intestine, fetal brain and colon, and weakly expressed in adult brain, ovary, prostate, pancreas and skeletal muscle. Gremlin functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with, BMP2, BMP4, and BMP7, thus preventing them from interacting with their cell surface receptors. This mechanism is thought to be responsible for the pattern-inducing activity of Gremlin during embryonic development and to play a role in human diseases, such as diabetic nephropathy. However, intracellular BMP-independent mechanisms of action may mediate the ability of Gremlin to suppress transformation and tumor genesis under certain experimental conditions. Gremlin also interacts with Slit proteins and acts as an inhibitor of monocyte chemotaxis. In addition, Gremlin has been found to be a proangiogenic factor expressed by endothelium. Furthermore Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2.
- Formulation:
- lyophilized
- Host:
- Rabbit
- Immunogen:
- Recombinant mouse Gremlin-1 (RT #M30-025)
- Purification:
- Protein A Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Polyclonal Antibody